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Epiregulin is a 5.4 kDa protein and member of the epidermal growth factor (EGF) family. Epiregulin binds to ErbB proteins to regulate signaling in development, including the development of tumors. Epiregulin regulates inflammation, wound healing, tissue repair, and oocyte maturation through stimulus of angiogenesis, vascular remodeling, and cell proliferation.